1312700-22-3

Upstream product

• 115393-77-6 tert-butyl (S)-2-vinylpyrrolidine-1-carboxylate 
• 69610-41-9 Boc-L-Pro-H 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 625-38-7 but-3-enoic acid 
• 1312700-23-4 (S)-2-(3-(benzyloxy)prop-1-en-2-yl)pyrrolidine 
• 1312700-27-8 tert-butyl (S)-2-(3-(benzyloxy) prop-1-en-2-yl)pyrrolidine-1-carboxylate 
• 1312700-26-7 tert-butyl (S)-2-(2-(benzyloxy)acetyl)pyrrolidine-1-carboxylate 
• 1312700-24-5 tert-butyl (2S)-2-(1,2-dihydroxyethyl)pyrrolidine-1-carboxylate 

Downstream Products

• 1312700-31-4 (S)-8-(benzyloxymethyl)-1,2,3,8a-tetrahydroindolizin-5(6H)-one 
• 1312700-32-5 ((8S,8aS)-5-oxo-octahydroindolizin-8-yl)methyl benzoate 

Relevant academic research and scientific papers

A common approach to pyrrolizidine and indolizidine alkaloids; Formal synthesis of (-)-isoretronecanol, (-)-trachelanthamidine and an approach to the synthesis of (-)-5-epitashiromine and (-)-tashiromine

A common and short stereoselective route is described for the formal synthesis of pyrrolizidine alkaloids, (-)-isoretronecanol and (-)-trachelanthamidine. An approach to the synthesis of indolizidine alkaloids (-)-5-epitashiromine and (-)-tashiromine utilizing ring closing metathesis is also described starting from commercially available and inexpensive l-proline.