1312715-86-8

Basic information

• Product Name: 10-bromo-3-nitro-7,8,11b⁽¹¹⁾-triazabenzo[c]fluorene
• Synonyms: 10-bromo-3-nitro-7,8,11b⁽¹¹⁾-triazabenzo[c]fluorene
• CAS NO: 1312715-86-8
• Molecular Weight: 343.139
• Mol File: 1312715-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 10-bromo-3-nitro-7,8,11b⁽¹¹⁾-triazabenzo[c]fluorene(CAS DataBase Reference)
• NIST Chemistry Reference: 10-bromo-3-nitro-7,8,11b⁽¹¹⁾-triazabenzo[c]fluorene(1312715-86-8)
• EPA Substance Registry System: 10-bromo-3-nitro-7,8,11b⁽¹¹⁾-triazabenzo[c]fluorene(1312715-86-8)

Safety Data

• Hazardous Substances Data: 1312715-86-8(Hazardous Substances Data)

Upstream product

• 36015-19-7 (E)-3-(2-chloro-5-nitrophenyl)-2-propenoic acid 

Relevant articles and documents

Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies

In the present paper, we have described the synthesis and biological activity of the novel derivatives of imidazo[4,5-b]pyridines and triaza-benzo[c]fluorenes (7-21, 24-26, 28-29). A preponderance of these compounds exerted strong cytostatic effects on the panel of seven human tumour cell lines in a dose-dependent manner. In particular, imidazo[4,5-b]pyridines and triaza-benzo[c]fluorenes including 2-imidazolinyl derivatives showed the most potent antitumour activity. Similarly, triaza-benzo[c]fluorenes 18 and 20 induced strong growth inhibition of tested tumour cell lines, and showed low cytotoxicity in normal human fibroblasts. DNA interaction studies of these compounds demonstrated that N-methylated 16 and 2-imidazolinyl 28 triaza-benzo[c]fluorenes bind to DNA in an intercalative mode.