1312749-57-7

Basic information

• Product Name: N-(2S)-3-hydroxypropan-2-yl-N'-(3,5-bis-(trifluoro-methyl)phenyl)-thiourea
• Synonyms: N-(2S)-3-hydroxypropan-2-yl-N'-(3,5-bis-(trifluoro-methyl)phenyl)-thiourea
• CAS NO: 1312749-57-7
• Molecular Weight: 346.296
• Mol File: 1312749-57-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2S)-3-hydroxypropan-2-yl-N'-(3,5-bis-(trifluoro-methyl)phenyl)-thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2S)-3-hydroxypropan-2-yl-N'-(3,5-bis-(trifluoro-methyl)phenyl)-thiourea(1312749-57-7)
• EPA Substance Registry System: N-(2S)-3-hydroxypropan-2-yl-N'-(3,5-bis-(trifluoro-methyl)phenyl)-thiourea(1312749-57-7)

Safety Data

• Hazardous Substances Data: 1312749-57-7(Hazardous Substances Data)

Upstream product

• 2749-11-3 (S)-Alaninol 
• 23165-29-9 3,5-bistrifluoromethylphenylisothiocyanate 

Relevant articles and documents

Readily available hydrogen bond catalysts for the asymmetric transfer hydrogenation of nitroolefins

This paper focuses on readily accessible thiourea hydrogen bond catalysts derived from amino acids, whose steric and electronic features are modulated by their degree of substitution at the carbinol carbon center. These catalysts were applied in the asymmetric transfer hydrogenation of nitroolefins furnishing the chiral products in up to 99% yield and 86% enantiomeric excess. The proposed catalyst's mode of action is supported by mechanistic investigations.