131275-69-9Relevant academic research and scientific papers
Chemoselective catalytic conjugate addition of alcohols over amines
Uesugi, Shuhei,Li, Zhao,Yazaki, Ryo,Ohshima, Takashi
supporting information, p. 1611 - 1615 (2014/03/21)
A highly chemoselective conjugate addition of alcohols in the presence of amines is described. The cooperative nature of the catalyst enabled chemoselective activation of alcohols over amines, allowing the conjugate addition to soft Lewis basic α,β-unsaturated nitriles. Divergent transformation of the nitrile functionality highlights the utility of the present catalysis. The cooperative nature of a copper catalyst enabled the highly chemoselective activation of alcohols in the presence of amines and thus the conjugate addition of the hydroxy group to soft Lewis basic α,β-unsaturated nitriles. The presented method proceeds under proton-transfer conditions, reverses the innate reactivity of the OH and NH groups, and does not require protecting groups. dppe=1,2-bis(diphenylphosphino) ethane, MeSal=3-methylsalicylate. Copyright
Antimalarial Polyamine Analogues
Edwards, M. L.,Stemeric, D. M.,Bitonti, A. J.,Dumont, J. A.,McCann, P. P.,et al.
, p. 569 - 574 (2007/10/02)
A series of novel tetraamines of the general formula RNH(CH2)xNH(CH2)yNH(CH2)xNHR was synthesized and examined for activity against growth of Plasmodium falciparum in vitro.Within the series, dibenzyl analogues (R = benzyl) were found to be the most effec
