131275-78-0Relevant articles and documents
Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid–pyrimidine conjugates
Kaur, Hardeep,Singh, Lovepreet,Chibale, Kelly,Singh, Kamaljit
, p. 949 - 955 (2019/11/14)
Abstract: Designing small molecule-based new drug candidates through structure modulation of the existing drugs has drawn considerable attention in view of inevitable emergence of resistance. A new series of isoniazid–pyrimidine conjugates were synthesize
Primaquine-pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity
Kaur, Hardeep,Machado, Marta,De Kock, Carmen,Smith, Peter,Chibale, Kelly,Prudêncio, Miguel,Singh, Kamaljit
, p. 266 - 273 (2015/07/08)
Abstract A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver
Synthesis of enantiomerically pure 4-aryl-3,4-dihydropyrimidin-2(1H)-ones via enzymatic resolution: preparation of the antihypertensive agent (R)-SQ 32926
Schnell, Barbara,Strauss, Ulrike T.,Verdino, Petra,Faber, Kurt,Kappe, C. Oliver
, p. 1449 - 1453 (2007/10/03)
A practical and short synthesis of the enantiomerically pure dihydropyrimidone antihypertensive agent (R)-SQ 32926 has been developed. The key step in the synthesis is the enzymatic resolution of an N3-acetoxymethyl-activated dihydropyrimidone precursor b