1312755-46-6

Basic information

• Product Name: 2-PyridinaMine, 5-fluoro-3-(1-propyn-1-yl)-
• Synonyms: 2-PyridinaMine, 5-fluoro-3-(1-propyn-1-yl)-
• CAS NO: 1312755-46-6
• Molecular Formula: C₈H₇FN₂
• Molecular Weight: 150.1529832
• Mol File: 1312755-46-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PyridinaMine, 5-fluoro-3-(1-propyn-1-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PyridinaMine, 5-fluoro-3-(1-propyn-1-yl)-(1312755-46-6)
• EPA Substance Registry System: 2-PyridinaMine, 5-fluoro-3-(1-propyn-1-yl)-(1312755-46-6)

Safety Data

• Hazardous Substances Data: 1312755-46-6(Hazardous Substances Data)

Upstream product

• 869557-43-7 3-bromo-5-fluoropyridin-2-amine 
• 74-99-7 prop-1-yne 
• 21717-96-4 2-amino-5-fluoropyridine 
• 823218-51-5 5-fluoro-3-iodo-pyridin-2-amine 

Downstream Products

• 1312755-51-3 9-benzenesulfonyl-5-chloro-3-fluoro-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312755-50-2 1-benzenesulfonyl-5-fluoro-2-{[cyanomethyl-(toluene-4-sulfonyl)amino]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1312755-49-9 1-benzenesulfonyl-5-fluoro-2-bromomethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1312755-48-8 1-benzenesulfonyl-5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1312755-47-7 5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1312755-45-5 9-benzenesulfonyl-3-fluoro-5-hydroxy-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 145934-92-5 5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

JNJ-63623872 (2) is a first-in-class, orally bioavailable compound that offers significant potential for the treatment of pandemic and seasonal influenza. Early lead optimization efforts in our 7-azaindole series focused on 1,3-diaminocyclohexyl amide and urea substitutions on the pyrimidine-7-azaindole motif. In this work, we explored two strategies to eliminate observed aldehyde oxidase (AO)-mediated metabolism at the 2-position of these 7-azaindole analogues. Substitution at the 2-position of the azaindole ring generated somewhat less potent analogues, but reduced AO-mediated metabolism. Incorporation of a ring nitrogen generated 7-azaindazole analogues that were equipotent to the parent 2-H-7-azaindole, but surprisingly, did not appear to improve AO-mediated metabolism. Overall, we identified multiple 2-substituted 7-azaindole analogues with enhanced AO stability and we present data for one such compound (12) that demonstrate a favorable oral pharmacokinetic profile in rodents. These analogues have the potential to be further developed as anti-influenza agents for the treatment of influenza.

1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER

The invention relates to 1, 7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk 1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.