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1312762-44-9

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  • (3R,4R)-4-Methyl-3-methylamino-piperidine-1-carboxylic acid tert-butyl ester

    Cas No: 1312762-44-9

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1312762-44-9 Usage

General Description

The chemical (3R, 4R)-4-Methyl-3-MethylaMino-piperidine-1-carboxylic acid tert-butyl ester is a compound that belongs to the class of piperidine derivatives. It is a tert-butyl ester derivative of a specific amino acid, and its chemical structure consists of a piperidine ring with a methyl and a methylamino group attached to it. (3R, 4R)-4-Methyl-3-MethylaMino-piperidine-1-carboxylic acid tert-butyl ester is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active molecules. Its specific stereochemical configuration (3R, 4R) gives it certain properties and reactivity that make it useful for specific chemical reactions.

Check Digit Verification of cas no

The CAS Registry Mumber 1312762-44-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,2,7,6 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1312762-44:
(9*1)+(8*3)+(7*1)+(6*2)+(5*7)+(4*6)+(3*2)+(2*4)+(1*4)=129
129 % 10 = 9
So 1312762-44-9 is a valid CAS Registry Number.

1312762-44-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R,4R)-1-Boc-4-methyl-3-methylamino-piperidine

1.2 Other means of identification

Product number -
Other names cis-(3R,4R)-N-(tert-butoxycarbonyl)-4-methyl-3-(methylamino)piperidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1312762-44-9 SDS

1312762-44-9Relevant articles and documents

Synthetic method for compound

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Paragraph 0051-0053; 0059-0060; 0062-0063, (2019/12/25)

The invention provides a synthetic method for a compound having a structural formula represented by a formula (V) shown in the specification. The method comprises the following steps: 1) performing hydrodebenzylation on a compound having a structural formula represented by a formula (I) shown in the specification to obtain a compound having a structural formula represented by a formula (II) shownin the specification; 2) allowing a compound having a structural formula represented by a formula (III) to be in contact with the compound having the structural formula represented by the formula (II)to obtain a compound having a structural formula represented by a formula (IV) shown in the specification; and 3) allowing the compound having the structural formula represented by the formula (IV) to be in contact with an acid solution to remove t-butoxycarbonyl protection, so as to obtain the compound having the structural formula represented by the formula (V). The synthetic method provided bythe invention has the advantages of a short synthetic route, a simple process, easy availability of the raw materials, simple post-treatment, good quality and a high yield, and is suitable for industrial production of tasocitinib and an intermediate of the tasocitinib.

The protection of the nitrogen of (3R, 4R) -3 - methylamino -4 - methyl piperidine asymmetric synthesis method, relevant intermediate and a method for preparing raw materials thereof

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, (2016/10/09)

The invention relates to a preparation method of nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I). The method comprises the following steps: carrying out a reductive amination reaction on a compound of formula (III) and (R)-1-phenylethylamine to obtain a compound of formula (II), removing chiral prosthetic groups from the compound of formula (II), and adding a methyl group to the amino group of the compound of formula (II) in order to obtain nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I), wherein R in each of the formula (I), the formula (II) and the formula (III) is an amino protection group or hydrogen, and the amino protection group can be C1-4 alkoxycarbonyl, benzyloxycarbonyl or benzyl groups which can be removed through hydrolysis or hydrogenation. The asymmetric synthesis method of nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I) has the advantages of reasonable technology, concise route, obtaining of the required product in a high ee value manner by constructing two chiral centers through chiral induced one-step reductive amination, cheap raw materials, and no waste isomer emission, and is suitable for large-scale industrialized production.

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