13128-94-4Relevant academic research and scientific papers
Asymmetric desymmetrization of meso-pyrrolidine derivatives by enantiotopic selective C-H hydroxylation using (salen)manganese(III) complexes
Punniyamurthy,Katsuki, Tsutomu
, p. 9439 - 9454 (2007/10/03)
Chiral (salen)manganese(III) complexes 1 catalyzed the asymmetric desymmetrization of N-protected meso-pyrrolidine derivatives 3, 6-8, 15 and 18 by enantiotopic selective C-H oxidation in the presence of terminal oxidant iodosylbenzene. The oxidation occurred chemoselectively at the carbon α to the nitrogen atom to afford optically active hydroxypyrrolidine derivatives 9, 11, 13, 16, 19 and 21 that were further oxidized to chiral lactams with Jones reagent. The N-protecting groups of the meso-pyrrolidine derivatives have notable effect on the enantioselectivity.
Conformations of Platinum-Coordinated Dimethylpyrrolidines. Crystal Structure of trans-.
Bachechi, Fiorella,Cellai, Luciano,Sparapani, Roberto,Paradisi, Mario Paglialunga
, p. 158 - 176 (2007/10/02)
The complex trans- has been synthesized and characterized by X-ray crystallography.It crystallizes in the orthorhombic space group Pbca with a = 14.685(5), b = 16.105(3), c = 20.400(7) Angstroem and Z = 8.The structure was solved by the heavy atom method and refined to R = 0.048 for 2109 observed counter reflections.The coordination sphere of the Pt atom is square-planar with a geometry very similar to that of the studied complexes of the type trans- where L is either one of the possible isomers of the C,C'-dimethylpyrrolidine or the unsubstituted pyrrolidine.In the present complex the puckered five-membered ring of the dimethylpyrrolidine ligand assumes a twist conformation with maximum puckering at carbon atoms C(2) and C(3).
