1312815-01-2Relevant academic research and scientific papers
Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series
Oubrie, Arthur,Kaptein, Allard,De Zwart, Edwin,Hoogenboom, Niels,Goorden, Rianne,Van De Kar, Bas,Van Hoek, Maaike,De Kimpe, Vera,Van Der Heijden, Ruud,Borsboom, Judith,Kazemier, Bert,De Roos, Jeroen,Scheffers, Michiel,Lommerse, Jos,Schultz-Fademrecht, Carsten,Barf, Tjeerd
, p. 613 - 618 (2012)
Optimization of our previously described pyrrolopiperidone series led to the identification of a new benzamide sub-series, which exhibits consistently high potency in biochemical and cell-based assays throughout the series. Strong inhibition of LPS-induce
SPIRO-CONDENSED PYRROLIDINE DERIVATIVES AS DEUBIQUITYLATING ENZYMES (DUB) INHIBITORS
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Page/Page column 99, (2017/09/15)
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1. The invention further relates to the use of DUB inhibitors in the treatment of cancer. (Figure (I))
MK2 INHIBITORS
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Page/Page column 48-49, (2011/07/07)
The present invention relates to compounds of general Formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used in the treatment of immune, autoimmune, inflammatory diseases, cardiovascular diseases, infectious diseases, bone re
