131286-33-4

Upstream product

• 668-72-4 Virginiamycin S₁ 
• 117505-35-8 (S)-2-({(S)-1-[(R)-2-((2S,3R)-2-[(3-Hydroxy-pyridine-2-carbonyl)-amino]-3-{(S)-2-[(4-oxo-piperidine-2-carbonyl)-amino]-2-phenyl-acetoxy}-butyrylamino)-butyryl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-phenyl-propionic acid; compound with trifluoro-acetic acid 
• 668-72-4 -Pic(3'-OH)-THr(O-Phg-(γ-oxo)Pec)-D-Abu-Pro-MePhe- 

Downstream Products

• 137407-82-0 (S)-2-({(S)-1-[(R)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-butyryl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-phenyl-propionic acid benzyl ester; compound with trifluoro-acetic acid 
• 137407-79-5 (S)-2-{[(S)-1-((R)-2-{(2S,3R)-2-[tert-Butoxycarbonyl-(3-tert-butoxycarbonyloxy-pyridine-2-carbonyl)-amino]-3-hydroxy-butyrylamino}-butyryl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionic acid benzyl ester 
• 137407-78-4 (S)-2-{[(S)-1-((R)-2-{(2S,3R)-3-Hydroxy-2-[(3-hydroxy-pyridine-2-carbonyl)-amino]-butyrylamino}-butyryl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionic acid benzyl ester 

Relevant academic research and scientific papers

UNEXPECTED INTERNAL PEPTIDE BUTOXYCARBONYLATION OF A LINEAR N-Me AMIDE PEPTIDE DERIVED FROM VIRGINIAMYCIN S AND RESULTING FAILURE FOR A CARBOXY-TERMINAL SEQUENCING. PREPARATION OF THE TETRAPEPTIDE SYNTHON Thr-D-Abu-Pro-MePhe-OBzl

Next to the preferential butoxycarbonylation of the picolinic hydroxyl group in Virginiamycin S1 (1a) and of VS-fragments derived therefrom, a second Boc-group is invariably and specifically implanted at the proximate amide bond preceding Thr (

CHARACTERISATION BY 2D PROTON NUCLEAR MAGNETIC RESONANCE METHODS OF Z/E ISOMERIC STATES OF THE LINEAR PENTAPEPTIDE PiC(3'-OH)-THR-ABU-PRO-MEPHE-OH DERIVED FROM VIRGINIAMYCIN S1

The four Z/E isomeric states of the linear pentapeptide Pic(3'-OH)-Thr-D-Abu-Pro-MePhe-OH are characterized by two-dimensional proton NMR methods and some of their conformational features are discussed. The title compound as obtained from Virginiamycin S1