13129-60-7

Usage

Synonyms

CPTHP

Chemical Class

Pyran derivatives

Physical State

Colorless, flammable liquid

Odor

Faint

Solubility

Insoluble in water, soluble in organic solvents

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals, solvent, reagent in organic synthesis

Health Hazards

Skin and eye irritation

Safety Measures

Handle and store with appropriate safety measures

Volatility

Low

Acute Toxicity

Low

InChI:InChI=1/C10H19ClO2/c11-7-3-1-4-8-12-10-6-2-5-9-13-10/h10H,1-9H2

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 5259-98-3 5-chloropentan-1-ol 
• 20395-28-2 5-chloropentyl acetate 
• 14273-86-0 methyl 5-chloropentanoate 

Downstream Products

• 37011-86-2 tetrahydro-2-(6-heptynyloxy)-2H-pyran 
• 100548-21-8 tert-Butyl-[1-methoxy-1-phenylsulfanyl-6-(tetrahydro-pyran-2-yloxy)-hexyl]-dimethyl-silane 
• 100548-11-6 [1-Methoxy-1-phenylsulfanyl-6-(tetrahydro-pyran-2-yloxy)-hexyl]-trimethyl-silane 
• 173542-25-1 3-<5-(tetrahydro-2-pyranyloxy)pentyl>-2-cyclohexen-1-one 
• 31502-19-9 (E)-6-nonen-1-ol 
• 20221-27-6 methyl (9E,12Z)-octadeca-9,12-dienoate 
• 171087-54-0 (8E,11Z)-1-bromoheptadeca-8,11-diene 
• 14113-05-4 (E)-10-hydroxy-dec-2-enoic acid 
• 54364-62-4 (7E,9Z)-7,9-dodecadien-1-yl acetate 

Relevant academic research and scientific papers

A NOVEL SYNTHESIS OF ROYAL JELLY ACIDS AND QUEEN SUBSTANCE BY THE FIVE CARBON HOMOLOGATION USING β-VINYL-β-PROPIOLACTONE

10-Hydroxy-(E)-2-decenoic acid, (E)-2-decenedioic acid (Royal jelly acids), and 9-oxo-(E)-2-decenoic acid (queen substance) were synthesized via 10-hydroxy-3-decenoic acid and 9,9-ethylenedioxy-3-decenoic acid, respectively, prepared easily by the regioselective ring-opening reaction of β-vinyl-β-propiolactone with Grignard reagents in the presence of copper(I) catalyst.

Synthesis of two novel oxocyclam-binding technetium complexes containing an analogue of cocaine

In order to visualize and quantify dopamine transporters, the synthesis of two novel ligands labelled with technetium-99m (99mTc) has been investigated. A multi-step synthesis afforded two target ligands with a tropane skeleton and a macrocycli

Nitroimidazoles and hypoxia imaging: Synthesis of three Technetium-99m complexes bearing a nitroimidazole group: Biological results

Several Tc-99m complexes were synthesized, substituted with a nitroimidazole group, in order to visualize hypoxic tissues. The complexes were tested on rats (isolated hearts) and showed no significant uptake under hypoxic conditions. (C) 2000 Elsevier Science Ltd.

New and simple syntheses of the attractants of the female melon fly, dacus cucurbitee

The attractant of the female melon fly, (E)-6-nonenyl acetate, and the two analogs, (E)-7-dodecenyl acetate and (E)-7-decenyl acetate were synthesized via hydrozirconation to control the regioselective coupling reactions and resulted in good yields.

POLYMERIZABLE COMPOUND AND OPTICAL ANISOTROPIC BODY

To provide a polymerizable compound giving such properties when added to a solution comprising a polymerizable composition that the resultant polymerizable composition has high storage stability and can induce a liquid crystal phase alignment in a short t

PROTEOLYSIS-TARGETING PROTACS INDUCING DEGRADATION OF C-MIC PROTEIN

Disclosed are proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of c-MYC protein. The disclosed PROTACs typically include a first targeting moiety that binds to c-MYC (MC-MYC) which may be derived from a substituted heterocycle that binds to c-MYC such as a substituted pyrazole. The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). AS such, the disclosed PROTACS may be described as having a formula Mc-MYC-L-ME3 or ME3-L-Mc-MYC.

POLYMERIZABLE COMPOUND AND OPTICAL ISOMER

The present invention provides a polymerizable compound having high storage stability without causing crystal precipitation when added to a polymerizable composition. The present invention also provides a polymerizable composition containing the compound. When the filmy polymer produced through polymerization of the polymerizable composition is irradiated with UV light, it hardly discolors or peels from substrate. Further, the present invention provides a polymer produced through polymerization of the polymerizable composition and an optically anisotropic body using the polymer.

A BISPHENOL DERIVATIVE HAVING AN ESTER BOND

PROBLEM TO BE SOLVED: To provide a production intermediate useful for obtaining a compound having an ester bond, and a production method to obtain a compound having an ester bond, using the same, with convenience and high purity; specifically, to provide a bisphenol derivative having an ester bond, a method for producing the same, and a compound produced from the bisphenol derivative as an intermediate; and to further provide a polymer obtained by the polymerization of a polymerizable composition containing the compound produced from the bisphenol derivative as an intermediate, and an optical anisotropic body using the polymer. SOLUTION: A bisphenol derivative having an ester bond is represented by general formula (I-C), where at least one of A1 and A2 is substituted with one substituent L. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

Donepezil–melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments

Hybrid inhibitors of acetyl- and butyrylcholinesterase are compounds that combine structural motifs of two different classical inhibitors, leading to a dual binding ligand. A rapidly growing collection of those compounds involves a wide diversity of structural motifs, but the way of linking two active fragments and its impact on the affinity toward cholinesterases usually remains beyond the extent of investigation. We present hereby a detailed analysis of this aspect using melatonin–donepezil hybrids. A new series of compounds, in which two fragments are connected using a carbamate linker, exhibits excellent activity and selectivity toward butyrylcholinesterase.

POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY

The present invention provides a compound represented by the general formula (I), and a polymerizable composition containing the compound. When the polymerizable composition containing the compound represented by the formula (I) is used to form a filmy product, the resulting filmy product exhibits less change over time in phase difference and reverse wavelength dispersion and when the filmy polymer is irradiated with UV light, peeling from a substrate is unlikely to be caused. Further, the invention provides a polymer obtained through polymerization of the polymerizable composition and an optically anisotropic body obtained using the polymer.