1312923-99-1

Basic information

• Product Name: 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-fluorobenzonitrile
• Synonyms: 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-fluorobenzonitrile
• CAS NO: 1312923-99-1
• Molecular Weight: 236.248
• Mol File: 1312923-99-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-fluorobenzonitrile(1312923-99-1)
• EPA Substance Registry System: 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-fluorobenzonitrile(1312923-99-1)

Safety Data

• Hazardous Substances Data: 1312923-99-1(Hazardous Substances Data)

Upstream product

• 933585-20-7 3-bromo-5-fluorophenylamide 
• 887266-90-2 3-bromo-5-fluoro-benzoyl chloride 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 872428-46-1 5-methyl-2-((trimethylsilyl)ethynyl)pyridine 
• 179898-34-1 3-bromo-5-fluorobenzonitrile 
• 176548-70-2 3-bromo-5-fluorobenzoic acid 

Relevant articles and documents

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl) ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl) ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.