1312929-69-3Relevant academic research and scientific papers
Enantiocontrolled synthesis of β-branched α-amino acids by using CuI-catalyzed 1,4-addition of glycine imines to β-substituted gem-diactivated olefins
Hernandez-Toribio, Jorge,Arrayas, Ramon Gomez,Carretero, Juan C.
, p. 6334 - 6337 (2011)
Branching out! The catalytic asymmetric conjugate addition of glycinate Schiff bases to β-substituted gem-diactivated Michael acceptors under proton transfer conditions gives a variety of β-branched α-amino acids (see scheme; Dpm=diphenylmethylene, EWG=electron-withdrawing group) with excellent levels of diastereo- (typically syn/anti >90:10) and enantiocontrol (90-99 % ee). Copyright
