131293-07-7Relevant academic research and scientific papers
Catalytic syntheses of N-heterocyclic ynones and ynediones by in situ activation of carboxylic acids with oxalyl chloride
Boersch, Christina,Merkul, Eugen,Mueller, Thomas J. J.
supporting information; experimental part, p. 10448 - 10452 (2011/12/05)
Breaking the bottleneck: α-Keto carboxylic acids and N-heterocyclic carboxylic acids are activated in situ with oxalyl chloride then catalytically alkynylated to give ynediones and N-heterocyclic ynones efficiently in a one-pot fashion. 5-Acylpyrazoles and 2-phenylaminopyrimidines, potentially interesting for pharmaceutical applications, are readily synthesized in concise one-pot, three-component syntheses. Copyright
ISOMERIZATION OF α-ACETYLENIC KETONES
Shvartsberg, M. S.,Fedenok, L. G.
, p. 1906 - 1910 (2007/10/02)
A method is suggested for isomerization of α-acetylenic ketones with migration of oxo group from position 1 to position 3 and of the triple bond position 2 to position 1 of the ketoacetylenic fragment; it consists of addition of Et2NH at the triple bond o
