1312945-55-3Relevant academic research and scientific papers
Thiourea-catalyzed asymmetric conjugate addition of α-substituted cyanoacetates to maleimides
Ma, Zhi-Wei,Wu, Ya,Sun, Bin,Du, Hai-Long,Shi, Wei-Min,Tao, Jing-Chao
, p. 7 - 13 (2013/02/23)
Chiral isosteviol-derived tertiary amine-thiourea was proven to be effective in catalyzing the asymmetric conjugate addition between α-substituted cyanoacetate and maleimides. Diverse succinimides bearing vicinal quaternary-tertiary stereocenters were obt
Organocatalytic asymmetric conjugate addition of α-substituted cyanoacetates to maleimides
Wang, Jin-Jia,Dong, Xue-Jiao,Wei, Wen-Tao,Yan, Ming
experimental part, p. 690 - 696 (2011/07/09)
The asymmetric conjugate addition of α-substituted cyanoacetates to N-substituted maleimides has been developed. A number of cinchona alkaloids and amine thioureas were evaluated as catalysts. Takemoto's catalyst was found to be the most efficient for the
