1312953-72-2Relevant academic research and scientific papers
Asymmetric palladium-catalyzed hydroarylation of styrenes and dienes
Podhajsky, Susanne M.,Iwai, Yasumasa,Cook-Sneathen, Amanda,Sigman, Matthew S.
, p. 4435 - 4441 (2011/08/06)
Alkenes are desirable and highly versatile starting materials for organic transformations, and well-known substrates for palladium catalysis. Typically, these reactions result in the formation of a new alkene product via β-hydride elimination. In contrast to this scenario, our laboratory has been involved in the development of alkene hydro- and difunctionalization reactions, where β-hydride elimination can be controlled. We report herein the development of an asymmetric palladium-catalyzed hydroarylation, which yields diarylmethine products in up to 75% ee. Interestingly, a linear free energy relationship is observed between the steric bulk of the ligand within a certain range and the ee of the reaction.
