1312991-08-4

Basic information

• Product Name: 3-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione
• Synonyms: 3-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione;3-[[(1S,2S)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4- (trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione,99%e.e.;3-[[(1S,2S)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 95%, (99% ee)
• CAS NO: 1312991-08-4
• Molecular Formula: C₂₂H₂₆F₃N₃O₂
• Molecular Weight: 421.4559496
• Mol File: 1312991-08-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 252 °C (decomp)
• Boiling Point: 497.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• PKA: 8.97±0.20(Predicted)
• CAS DataBase Reference: 3-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione(1312991-08-4)
• EPA Substance Registry System: 3-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione(1312991-08-4)

Safety Data

• Hazardous Substances Data: 1312991-08-4(Hazardous Substances Data)

Upstream product

• 111-30-8 Glutaraldehyde 
• 21436-03-3 (S,S)-1,2-diaminocyclohexane 
• 824938-80-9 (1S, 2S)-trans-2-(1-piperidinyl)cyclohexylamine 

Relevant articles and documents

Chiral squaramide-catalyzed highly enantioselective michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes

A chiral squaramide-organocatalyzed, highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes has been developed. This reaction afforded the chiral naphthoquinones in excellent yields (up to 99%) and excellent enantioselectivity (up to 98% ee) under very low catalyst loading (0.25 mol%). This organocatalytic asymmetric Michael addition provides an efficient alternative route toward the synthesis of chiral functionalized naphthoquinones.