1313022-60-4

Upstream product

• 924906-60-5 N-(prop-2-ynyl)-N-[2-(tert-butyldimethylsilanyloxy)ethyl]amine 
• 1313022-54-6 N-(2-(tert-butyldimethylsilyloxy)ethyl)-uracil-1-yl-N-(prop-2-yn-1-yl)acetamide 
• 1313022-56-8 ethyl 2-(N-(2-azidoethyl)-uracil-1-yl-acetamido)acetate 
• 1313022-57-9 ethyl 2-(N-(2-(4-((N-(2-(tert-Butyldimethylsilyloxy)ethyl)-uracil-1-yl-acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-uracil-1-yl-acetamido)acetate 
• 1313022-58-0 N-(2-(tert-butyldimethylsilyloxy)ethyl)-uracil-1-yl-N-((1-(2-(uracil-1-yl-N-(2-hydroxyethyl)acetamido)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide 
• 1313022-59-1 N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)-N-(2-(4-((2-(uracil-1-yl)-N-(2-((2,3,3-trimethylbutan-2-yl)oxy)ethyl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)acetamide 

Downstream Products

• 1313022-61-5 2-(N-(2-(4-((N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)-2-(uracil-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite 

Relevant academic research and scientific papers

Synthesis and properties of oligonucleotides that contain a triazole-linked nucleic acid dimer

New chemically modified oligonucleotides at the site of the backbone are needed to improve the properties of oligonucleotides. A practical synthesis for a triazole-linked nucleoside dimer based on a PNA-like structure has been developed. This involves synthesizing two uracil-based monomers that contain either an azide or an alkyne functionality, followed by copper-catalyzed 1,3-dipolar cycloaddition. This dimer was incorporated within an oligonucleotide via phosphoramidite chemistry and UV-monitored thermal denaturation data illustrates slight destabilization relative to its target complementary sequence. This chemically modified dimer will allow for a future investigation of its properties within DNA and RNA-based applications.