1313033-58-7Relevant academic research and scientific papers
Regioselective addition of Grignard reagents to N-acylpyrazinium salts: Synthesis of substituted 1,2-dihydropyrazines and Δ5-2-oxopiperazines
St Hilaire, Valentine R.,Hopkins, William E.,Miller, Yenteeo S.,Dandepally, Srinivasa R.,Williams, Alfred L.
, p. 72 - 78 (2019)
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihy-dropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines can be converted to substituted Δ5-2-oxopiperazines providing a simple and efficient approach towards their preparation.
JBIR-56 and JBIR-57, 2(1 H)-pyrazinones from a marine sponge-derived streptomyces sp. SpD081030SC-03
Motohashi, Keiichiro,Inaba, Kennichi,Fuse, Shinichiro,Doi, Takayuki,Izumikawa, Miho,Khan, Shams Tabrez,Takagi, Motoki,Takahashi, Takashi,Shin-Ya, Kazuo
experimental part, p. 1630 - 1635 (2011/09/16)
Strain SpD081030SC-03, representing a novel species of Streptomyces, was isolated from a marine sponge. Two 3,5,6-trisubstituted 2(1H)-pyrazinones, JBIR-56 (1) and JBIR-57 (2), were isolated from a culture of SpD081030SC-03. The planar structures of 1 and
