1313041-73-4

Upstream product

• 79568-30-2 4,4-dimethyl-2-p-tolyl-2-oxazoline 
• 104-87-0 4-methyl-benzaldehyde 
• 866526-26-3 2-(2-bromo-4-methylphenyl)-4,4-dimethyl-4,5-dihydrooxazole 
• 345953-43-7 4-(bromomethyl)-2-bromobenzaldehyde 

Downstream Products

• 1313041-75-6 3-bromo-4-difluoromethyl-benzylamine 
• 1313041-74-5 4-azidomethyl-2-bromo-1-difluoromethyl-benzene 
• 1313041-78-9 N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride 
• 1313041-77-8 N-(4-difluoromethyl-3-pyridin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride 
• 1313041-76-7 4-difluoromethyl-3-pyridin-4-yl-benzylamine 

Relevant academic research and scientific papers

Clickable azide-functionalized bromoarylaldehydes – synthesis and photophysical characterization

Herein, we present a facile synthesis of three azide-functionalized fluorophores and their covalent attachment as triazoles in Huisgen-type cycloadditions with model alkynes. Besides two ortho- and para-bromo-substituted benzaldehydes, the azide functionalization of a fluorene-based structure will be presented. The copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) of the so-synthesized azide-functionalized bromocarbaldehydes with terminal alkynes, exhibiting different degrees of steric demand, was performed in high efficiency. Finally, we investigated the photophysical properties of the azide-functionalized arenes and their covalently linked triazole derivatives to gain deeper insight towards the effect of these covalent linkers on the emission behavior.

INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS

The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines. In one of the embodiments, there is provided the compounds of formula (I) wherein R3 is (II).