131309-64-3

Upstream product

• 36106-45-3 2-acetyl-2-phenyl-1,3-dithiane 
• 5425-44-5 2-Phenyl-[1,3]dithiane 

Downstream Products

• 2060-65-3 2-phenyl tetrahydro thiophene 

Relevant academic research and scientific papers

An efficient solvent free catalytic oxidation of sulfides to sulfoxides with hydrogen peroxide catalyzed by a binaphthyl-bridged Schiff base titanium complex

A titanium binaphthyl-bridged Schiff base complex proved to be an efficient catalyst for the hydrogen peroxide oxidation of aromatic and aliphatic sulfides to the corresponding sulfoxides in satisfactory yields under solvent-free conditions.

Metal- and additive-free oxygen-atom transfer reaction: an efficient and chemoselective oxidation of sulfides to sulfoxides with cyclic diacyl peroxides

Metal- and additive-free oxidation of a series of sulfides/thioketones has been achieved using cyclic diacyl peroxides as mild oxygen sources. This protocol features simple manipulation, high chemo- and diastereoselectivity, and a broad substrate scope (up to 42 examples), tolerates many common functional groups, and is scalable and applicable to the late-stage sulfoxidation strategy. A preliminary mechanistic study by quantum mechanical calculations suggests that a single two-electron transfer process is energetically more favorable, and indicates the reactivity of cyclic diacyl peroxides distinct from conventional acyclic acyl peroxides.

Polyoxomolybdate-Calix[4]arene Hybrid: A Catalyst for Sulfoxidation Reactions with Hydrogen Peroxide

An easily accessible polyoxomolybdate-calix[4]arene hybrid 1 has been synthesized and applied as a heterogeneous catalyst in the sulfoxidation of thioethers to sulfoxides and to sulfones under strictly stoichiometric amounts of 30% H2O2 in CH3CN as the solvent. This study represents the first promising example of successful employment of calixarenes-polyoxometalate (POM) hybrid materials in the area of catalytic oxidations.

Chiral phosphoric acid-catalyzed asymmetric oxidation of aryl alkyl sulfides and aldehyde-derived 1,3-dithianes: Using aqueous hydrogen peroxide as the terminal oxidant

(R)-1,1'-Binaphthyl-2,2'-diol (R-BINOL) derived chiral phosphoric acids have been explored as organocatalysts for the asymmetric oxidation of a series of aryl alkyl sulfides and 1,3-dithianes derived from aldehydes with aqueous hydrogen peroxide (H2O2) as the terminal oxidant. The enantiomerically enriched sulfoxides are obtained in moderate to excellent yield (up to 99%) with excellent diastereoselectivity (up to >99:1 dr) and moderate to good enantioselectivity (up to 91:9 er). In particular, the present protocol stereoselectively provides an efficient access to enantiomerically enriched aryl alkyl sulfoxides and dithioacetal mono-sulfoxides, which strictly restrains the formation of the undesirable by-products: sulfones or disulfoxides. The tracking experiments also verify that this approach proceeds via a direct sulfoxidation process, instead of a kinetic resolution route by overoxidation of the resulting sulfoxides. Copyright

Enantioselective vanadium-catalyzed oxidation of 1,3-dithianes from aldehydes and ketones using β-amino alcohol derived schiff base ligands

The asymmetric vanadium-catalyzed oxidation of 1,3-dithianes from aldehydes and ketones by β-amino alcohol-derived Schiff base ligands with two stereogenic centers was investigated. Using aqueous hydrogen peroxide as the oxidant and the Schiff base 3b as

Titanocene dichloride as a convenient catalyst for the diastereoselective oxidation of 2-substituted 1,3-dithianes and 1,3-dithiolanes

Cp2TiCl2 is an efficient catalyst for the diastereoselective mono-oxidation of 2-substituted 1,3-dithianes and 1,3-dithiolanes by tert-butyl hydroperoxide; comparable stereoselectivities and better yields than Ti(i-PrO)4 w

Substituted N-Salicylidene β-Amino Alcohols. Preparation and Use as Chiral Ligands in Enantioselective Sulfoxidation and Conjugate Addition

A high-yielding synthesis of optically active 3,5-disubstituted N-salicylidene β-amino alcohols 6, versatile chiral ligands, is developed. The catalytic use of D or L-N-(3-phenyl-5-nitrosalicylidene)valinol (6j) in enantioselective sulfoxidation reactions (H2O2/VO(acac)2) gives up to 95 percent e.e. The asymmetric conjugate addition of thiophenol to 2-cyclohexen-1-one catalyzed by Ti(OPr-i)4 and 6 leads to maximum of 31 percent e.e.

Vanadium catalyzed enantioselective oxidation of sulfides: Easy transformation of bis(arylthio)alkanes into C2 symmetric chiral sulfoxides

A facile and selective method for the title transformation is described. The two-phase oxidation of bis-sulfides with hydrogen peroxide catalyzed by vanadium complex of chiral Schiff base leads to the corresponding chiral mono- and bis-sulfoxides. In the

Asymmetric oxidation of dithioacetals and dithioketals catalyzed by a chiral vanadium complex

Vanadium-catalyzed enantioselective oxidations of dithioacetals and dithioketals with 30% aqueous H2O2 give the corresponding monosulfoxides with enantioselectivities of up to 85% ee. The scope of this asymmetric catalysis has been i

Enantioselective preparation of 2-substituted-1,3-dithiane 1-oxides using modified Sharpless sulphoxidation procedures

Enantioselective sulphoxidation of a wide range of 2-substituted-1,3-diathianes has been carried out using modified Sharpless conditions to furnish the corresponding sulphoxides in optically enriched form. Deacylation of 2-acyl-1,3-dithiane 1-oxide deriva