131311-05-2Relevant academic research and scientific papers
Convergent Synthesis of the ent-ZA′B′C′D′-Ring System of Maitotoxin
Saito, Tatsuo,Morita, Masayuki,Koshino, Hiroyuki,Sodeoka, Mikiko,Nakata, Tadashi
, p. 3203 - 3206 (2017)
Stereoselective synthesis of the ent-ZA′B′C′D′-ring system of maitotoxin has been accomplished through a convergent strategy utilizing Suzuki-Miyaura cross coupling reaction of ZA′-ring alkylborane and C′D′-ring (Z)-vinyl iodide, and subsequent constructi
Synthesis and biological activity of the C'D'E'F' ring system of maitotoxin
Kunitake, Masahiro,Oshima, Takahiro,Konoki, Keiichi,Ebine, Makoto,Torikai, Kohei,Murata, Michio,Oishi, Tohru
, p. 4948 - 4962 (2014/06/23)
Stereoselective synthesis of the C'D'E'F' ring system of maitotoxin was achieved starting from the E' ring through successive formation of the D' and C' rings based on SmI2-mediated reductive cyclization. Construction of the F' ring was accomplished via Suzuki-Miyaura cross-coupling with a side chain fragment and Pd(II)-catalyzed cyclization of an allylic alcohol. The C'D'E'F' ring system inhibited maitotoxin-induced Ca2+ influx in rat glioma C6 cells with an IC50 value of 59 μM.
