1313199-72-2Relevant academic research and scientific papers
Synthesis and biological evaluation of bilobol and adipostatin A
Tanaka, Ayano,Arai, Yasuhiro,Kim, Su-Nam,Ham, Jungyeob,Usuki, Toyonobu
experimental part, p. 290 - 296 (2011/06/19)
Concise total synthesis of bilobol 5-pentadecenylresorcinol (1), isolated from Gingko biloba fruits, has been achieved in 10 steps with 51% overall yield from 3,5-dihydroxybenzoic acid (3). Adipostatin A (2), isolated from the fruits as well as from Streptomyces cyaneus 2299-SV1, has also been synthesized in two steps from methylated bilobol (10). The structure-activity relationship study of synthetic products was described by means of cytotoxic assay against human KB carcinoma cell lines.
