1313364-76-9

Basic information

• Product Name: [4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid
• Synonyms: [4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid
• CAS NO: 1313364-76-9
• Molecular Weight: 238.284
• Mol File: 1313364-76-9.mol

Chemical Properties

• CAS DataBase Reference: [4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid(1313364-76-9)
• EPA Substance Registry System: [4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid(1313364-76-9)

Safety Data

• Hazardous Substances Data: 1313364-76-9(Hazardous Substances Data)

Upstream product

• 15964-80-4 2-(4-hydroxy-3-methoxyphenyl)acetic acid methyl ester 
• 1313364-75-8 [4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid ethyl ester 
• 60563-13-5 ethyl homovanillate 

Downstream Products

• 1313364-77-0 [4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetyl chloride 
• 1313359-32-8 7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-2-(4-dimethylamino-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one trifluoroacetate 
• 1313365-33-1 7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one 
• 1313365-34-2 2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 1313361-51-1 7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-{4-[(pyridin-4-ylmethyl)-amino]-phenyl}-1,4-dihydro-2H-isoquinolin-3-one 

Relevant articles and documents

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode

Blocking the interaction between the p53 tumor suppressor and its regulatory protein MDM2 is a promising therapeutic concept under current investigation in oncology drug research. We report here the discovery of the first representatives of a new class of small molecule inhibitors of this protein-protein interaction: the dihydroisoquinolinones. Starting from an initial hit identified by virtual screening, a derivatization program has resulted in compound 11, a low nanomolar inhibitor of the p53-MDM2 interaction showing significant cellular activity. Initially based on a binding mode hypothesis, this effort was then guided by a X-ray co-crystal structure of MDM2 in complex with one of the synthesized analogs. The X-ray structure revealed an unprecedented binding mode for p53-MDM2 inhibitors.

Substituted Isoquinolinones and Quinazolinones

The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.