1313367-41-7

Upstream product

• 1313366-30-1 1-(4-Chloro-phenyl)-7-hydroxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 1313366-29-8 1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 4468-59-1 4-hydroxy-3-methoxyphenylacetonitrile 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1313367-40-6 1-(4-chloro-phenyl)-7-isopropoxy-6-d3-methoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 1416909-67-5 1-(4-chloro-phenyl)-7-isopropoxy-6-(4-methoxy-benzyloxy)-1,4-dihydro-2H-isoquinolin-3-one 
• 1416909-63-1 (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(2-methoxy-ethoxy)-1,4-dihydro-2H-isoquinolin-3-one 
• 1416909-64-2 (S)-1-(4-chloro-phenyl)-6-hydroxy-7-isopropoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 1416909-66-4 (R)-1-(4-chloro-phenyl)-7-isopropoxy-6-(4-methoxy-benzyloxy)-1,4-dihydro-2H-isoquinolin-3-one 
• 1416909-65-3 (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(4-methoxy-benzyloxy)-1,4-dihydro-2H-isoquinolin-3-one 
• 1416909-70-0 (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-(pyridin-2-ylmethoxy)-1,4-dihydro-2H-isoquinolin-3-one 
• 1416909-74-4 2-[(S)-1-(4-chloro-phenyl)-7-isopropoxy-3-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yloxy]-N-methyl-acetamide 
• 1416909-75-5 [(S)-1-(4-Chloro-phenyl)-7-isopropoxy-3-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yloxy]-acetic acid methyl ester 
• 1416909-80-2 (R)-1-(4-chloro-phenyl)-7-isopropoxy-6-d3-methoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 1416909-79-9 (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-d3-methoxy-1,4-dihydro-2H-isoquinolin-3-one 

Relevant academic research and scientific papers

HYDROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES

The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.