1313372-75-6

Basic information

• Product Name: 2H-Indazole, 3-methyl-6-nitro-
• Synonyms: Pazopanib Impurity 1;Pazopanib Impurity 15;2H-Indazole, 3-methyl-6-nitro-
• CAS NO: 1313372-75-6
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16
• Mol File: 1313372-75-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 225℃
• Flash Point: 90℃
• Appearance: /
• Density: 1.437
• PKA: 12.41±0.30(Predicted)
• CAS DataBase Reference: 2H-Indazole, 3-methyl-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indazole, 3-methyl-6-nitro-(1313372-75-6)
• EPA Substance Registry System: 2H-Indazole, 3-methyl-6-nitro-(1313372-75-6)

Safety Data

• Hazardous Substances Data: 1313372-75-6(Hazardous Substances Data)

Usage

General Description

The chemical 2H-Indazole, 3-methyl-6-nitro- is a compound with the molecular formula C9H8N4O2 and a molecular weight of 204.19 g/mol. It is a nitro derivative of 3-methyl-2H-indazole and is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. This chemical is known for its potential applications in medicinal chemistry, particularly in the development of new drugs for various therapeutic purposes. Its synthesis and properties have been studied extensively, and it is considered to be a valuable intermediate in organic chemistry. Additionally, 2H-Indazole, 3-methyl-6-nitro- may have potential uses in other fields such as materials science and agrochemicals.

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Downstream Products

• 444731-72-0 2,3-dimethyl-6-amino-2H-indazole 
• 1376676-65-1 N,2,3-trimethyl-2H-indazole-6-amine 
• 444731-75-3 N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine 
• 79173-62-9 3-methyl-2H-indazol-6-amine 

Relevant articles and documents

Preparation method of pazopanib intermediate

The invention provides a preparation method of a pazopanib key intermediate 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method comprises the following steps: by taking 6-halogenated-2,3-dimethyl-2H-indazole as a raw material, conducting reacting to obtain N,2,3-trimethyl-2H-indazole-6-amine; and further carrying out a reaction to obtain the 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method has the advantages of short synthesis route, accessible raw materials, low cost, mild reaction conditions, high safety and high yield, and is suitable for industrial mass production.

Hydrochloric acid [...] of the method for the preparation of intermediates

The invention discloses a preparation method of an intermediate (2,3-dimethyl-N-(2-chloropyrimidine-4-base)-N-methyl-2H-indazole-6-amine) of pazopanib hydrochloride as shown in a formula I. The preparation method comprises the step of performing nucleophilic substitution reaction on a compound III and 2,4-dichloropyrimidine in an organic solvent under the action of alkali, wherein the reaction temperature is 0-160 DEG C. According to the preparation method disclosed by the invention, raw materials are low in price and easy to obtain, and the preparation method is convenient to operate, high in product yield and suitable for industrial large-scale production.