1313372-75-6

Usage

Uses

Used in Pharmaceutical Industry:
2H-Indazole, 3-methyl-6-nitrois used as a key intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs. Its unique chemical structure allows for the creation of various therapeutic agents, contributing to the advancement of medicinal chemistry.
Used in Organic Chemistry Research:
As a valuable intermediate, 2H-Indazole, 3-methyl-6-nitrois utilized in organic chemistry for the synthesis of complex organic compounds. Its properties make it a versatile component in the development of novel chemical entities and the exploration of new reaction pathways.
Used in Materials Science:
2H-Indazole, 3-methyl-6-nitromay have potential applications in materials science, where its unique properties could be leveraged to develop new materials with specific characteristics, such as improved stability or reactivity.
Used in Agrochemicals:
2H-Indazole, 3-methyl-6-nitromay also find use in the agrochemical industry, where it could be employed in the development of new pesticides or other agricultural chemicals, enhancing crop protection and yield.

Upstream product

• 20191-74-6 2-ethyl-5-nitroaniline 
• 578-54-1 ortho-ethylaniline 
• 612-22-6 2-nitro(ethylbenzene) 

Downstream Products

• 79173-62-9 3-methyl-2H-indazol-6-amine 
• 444731-72-0 2,3-dimethyl-6-amino-2H-indazole 
• 1376676-65-1 N,2,3-trimethyl-2H-indazole-6-amine 
• 444731-75-3 N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine 

Relevant academic research and scientific papers

Preparation method of pazopanib intermediate

The invention provides a preparation method of a pazopanib key intermediate 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method comprises the following steps: by taking 6-halogenated-2,3-dimethyl-2H-indazole as a raw material, conducting reacting to obtain N,2,3-trimethyl-2H-indazole-6-amine; and further carrying out a reaction to obtain the 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method has the advantages of short synthesis route, accessible raw materials, low cost, mild reaction conditions, high safety and high yield, and is suitable for industrial mass production.

Method for preparing 2, 3-dimethyl-2H-indazole-6-benzylamine hydrochloride

The invention discloses a method for preparing 2, 3-dimethyl-2H-indazole-6-benzylamine hydrochloride. The method comprises the steps of reacting a glacial acetic acid solution of tert-butyl nitrite and a glacial acetic acid solution of 5-nitro-2-ethylaniline in a first microreactor to generate 3-methyl-6-nitro-1H-indazole; reacting a homogeneous solution formed by mixing the 3-methyl-6-nitro-1H-indazole and a dimethyl sulfoxide solution of methyl iodide and a dimethyl sulfoxide solution of sodium ethoxide in a second microreactor to generate 2,3-dimethyl-6-nitro-2H-indazole; then reacting withmixed liquor formed by stirring a concentrated hydrochloric acid solution of stannous chloride and ethyl alcohol in a third microreactor to generate the 2, 3-dimethyl-2H-indazole-6-benzylamine hydrochloride. The method provided by the invention has the advantages of less side reaction, high yield, simplification of a complicated multi-step synthesis process, low toxicity and pollution, low production cost, good product quality, environment friendliness, energy saving and high efficiency, and is suitable for industrialized application.

Hydrochloric acid [...] of the method for the preparation of intermediates

The invention discloses a preparation method of an intermediate (2,3-dimethyl-N-(2-chloropyrimidine-4-base)-N-methyl-2H-indazole-6-amine) of pazopanib hydrochloride as shown in a formula I. The preparation method comprises the step of performing nucleophilic substitution reaction on a compound III and 2,4-dichloropyrimidine in an organic solvent under the action of alkali, wherein the reaction temperature is 0-160 DEG C. According to the preparation method disclosed by the invention, raw materials are low in price and easy to obtain, and the preparation method is convenient to operate, high in product yield and suitable for industrial large-scale production.

METHODS FOR IDENTIFICATION OF JAK KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF JAK KINASES

The present invention relates to immobilization compounds and methods useful for the identification of JAK interacting compounds or for the purification or identification of JAK.