1313375-62-0Relevant articles and documents
NEW DENDRIMERIC PYRROLIDINES, THEIR SYNTHESIS AND MEDICAL USE
-
Page/Page column 15, (2017/09/05)
The subject-matter of the present invention relates to the synthesis of new dendrimeric molecules based on polyhydroxylated pyrrolidines obtained by means of Click Chemistry reactions. The proposed molecules inhibit the enzymes N-acetylgalactosamine-6-sulfatase (GALNS), iduronate-2-sulfatase (IDS), a-mannosidase and β-glucosidase, deficient in lysosomal storage diseases. The presentation of multivalent iminosugars on a scaffold is a prerequisite for the inhibitory activity as the corresponding monomers are not active. The inhibitory activity reported is the basis for the development of the first-ASSC pharmacological chaperones proposed for the treatment of the above mentioned pathologies. Formula (I)
Synthesis and characterization of some novel glycodendrimers and N-alkyldendrimers with amide core and triazole functionality through click chemistry
Rajakumar, Perumal,Anandhan, Ramasamy
supporting information, p. 2217 - 2225 (2013/07/25)
The syntheses of various types of 1,2,3-triazole-based dendrimers 1-4 with sugar pyranosylazides and N-ethyl and N-heptylazides as a surface unit and benzene-1,3,5- tricorboxlyic amide as core unit through click chemistry approach are described. Copyright