1313395-75-3Relevant academic research and scientific papers
A rapid and simple amine-catalyzed microwave-assisted isomerization of maleamides into fumaramides
Majce, Vita,Ko?evar, Marijan,Polanc, Slovenko
, p. 3287 - 3290 (2011/06/28)
An improved, efficient, and simple method for the synthesis of nonsymmetrical diamides of fumaric acid is reported. Starting from commercially available substrates, maleic diamides are formed in two steps, and then isomerized in a focused microwave reactor in acetonitrile as the solvent in the presence of a catalytic amount of piperidine, giving the corresponding fumaramides in high yields and purity.
