1313398-22-9

Upstream product

• 52157-62-7 2-(5-bromothiophen-2-yl)-1,3-dioxolane 
• 1313397-91-9 5-(5-(1,3-dioxolan-2-yl)thiophen-2-yl)isobenzofuran-1(3H)-one 
• 862081-37-6 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isobenzofuran-1(3H)-one 
• 1313397-92-0 5-(1-oxo-1,3-dihydroisobenzofuran-5-yl)thiophene-2-carbaldehyde 
• 1313399-76-6 diethyl 1-(4-methoxybenzyl)-2-oxopyrrolidin-3-ylphosphonate 

Relevant academic research and scientific papers

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones

An aryl-substituted isobenzofuran-1(3H)-one lead compound was identified from a high throughput screen designed to find inhibitors of the lymphocyte pore-forming protein perforin. A series of analogs were then designed and prepared, exploring structure-ac

COMPOUNDS, PREPARATIONS AND USES THEREOF

The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susc