1313408-93-3Relevant articles and documents
Synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel FMS inhibitors
Kim, Yu-Yon,Choi, Jaeyul,Choi, Kyungjin,Park, Changhee,Kim, Young Hoon,Suh, Kwee Hyun,Ham, Young Jin,Jang, Sun Young,Lee, Kyu-Hang,Hwang, Kwang Woo
supporting information, p. 271 - 275 (2018/12/11)
Colony stimulating factor-1 receptor (CSF-1R or FMS) and it ligand, CSF-1, signaling regulates the differentiation and function of tumor-associated macrophages (TAMs) that play an important role in tumor progression. Derivatives of thieno[3,2-d]pyrimidine were synthesized and evaluated as kinase inhibitors of FMS. The most representative compound 21 showed strong activity (IC50 = 2 nM) against FMS kinase and served as candidate for proof of concept. Anti-tumor activity alone and/or in combination with paclitaxel was examined via a tumor cell growth inhibition assay and via an in vitro tumor invasion assay using human breast adenocarcinoma cells.
SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS
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Page/Page column 87, (2012/06/30)
Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal
