1313429-38-7

Upstream product

• 1616-63-3 3-hydroxy-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid ethyl ester 
• 1404478-78-9 3-(3-methoxy-phenyl)-2-methyl-pent-3-enoic acid ethyl ester 
• 1616-70-2 2-methyl-3-(3-methoxyphenyl)valeric acid 
• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 37951-49-8 1-(3-methoxyphenyl)propan-1-one 
• 1313429-32-1 (αR,βR)-β-ethyl-3-methoxy-α-methylbenzenepropanoic acid 
• 1313429-34-3 (S),(S)-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid 
• 124-40-3 dimethyl amine 
• 1313374-18-3 (Z,E)-3-(3-methoxyphenyl)-N,N,2-trimethylpent-2-enamide 
• 1352230-10-4 3-hydroxy-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamide 
• 1313374-17-2 N,N-dimethyl-2-methyl-3-(3-methoxyphenyl)valeramide 

Downstream Products

• 175591-22-7 (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine 

Relevant academic research and scientific papers

A NOVEL PROCESS FOR THE PREPARATION OF TAPENTADOL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Disclosed herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R))-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, in high yield and purity. Also described are novel intermediates useful for preparing tapentadol or a pharmaceutically acceptable salt thereof.

PROCESS FOR THE PREPARATION OF 1-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES

A process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives of formula (I) and its pharmaceutically acceptable salts thereof from cyano intermediate of formula (II), wherein R1 can be selected from -OR2, halo, -CH2OR2, -SR2, -SOR2, SO2R2, -SO3H, -NO2, -NR2R2', -CONR2R2', carboxylic esters, sulfonate esters or phosphate esters, R2 and R2' can be same or different, and can be selected from hydrogen, alkyl, aryl, aralkyl, heteroaryl, -COR2", -P03(R2")2 wherein R2" can be selected from alkyl, aryl, aralkyl, heteroaryl and the like.

Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds

A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds.