131346-47-9Relevant academic research and scientific papers
Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1,6] naphthyridines at α-adrenoceptors
Clark,Repke,Berger,Nelson,Kilpatrick,Brown,MacKinnon,Clague,Spedding
, p. 705 - 717 (2007/10/02)
Analogues of the potent α2-adrenoceptor antagonist (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12- (methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine (1b) were prepared and evaluated for α1- and α2-
Process for the preparation of decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives
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, (2008/06/13)
The invention provides a process for preparing compounds, as a single enantiomer or mixture of enantiomers, represented by the formula: STR1 in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy, and Z is --SO2 R or --C(O)NR3 R4, in which; R is lower alkyl, optionally substituted phenyl, --(CH2)m OR1 or --NR1 R2 wherein m is an integer of 1 to 6 and R1 and R2 are independently hydrogen or lower alkyl; and R3 and R4 are independently hydrogen, alkyl, optionally substituted phenyl or phenyl lower alkyl; or R1 and R2 taken together with the nitrogen to which they are attached or R3 and R4 taken together with the nitrogen to which they are attached represent a heterocycle of the formula: STR2 wherein A is --CH2 --, --NR1 -- or oxygen; and novel intermediates.
Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as α2 -blockers
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, (2008/06/13)
Compounds of formulas (1) and (2): STR1 in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenendioxy or ethylene-1,2-dioxy, and R is lower alkyl, optionally substituted phenyl, --(C
