1313489-99-4Relevant academic research and scientific papers
Highly efficient synthesis of multisubstituted 2-acyl furans via PIFA/I2-mediated oxidative cycloisomerization of cis -2-En-4-yn-1-ols
Du, Xiangwei,Chen, Haoyi,Chen, Yifeng,Chen, Jingjin,Liu, Yuanhong
supporting information; experimental part, p. 1010 - 1014 (2011/06/17)
A novel oxidative cycloisomerization of cis-enynols has been developed using a combination of hypervalent iodine(III) reagent, molecular iodine, and a base. This method offers an efficient synthesis of 2-acyl furans with diverse substitution patterns in a -regioselective manner under mild reaction conditions. A mechanistic proposal for these transformations involving alkyne activation by trifluoroacetylhypoiodite generated in situ is presented. Georg Thieme Verlag Stuttgart · New York.
