131352-74-4

Basic information

• Product Name: 2-[(Z)-3,3'-Dibenzyl-5'-(2-hydroxy-ethyl)-4,4'-dimethyl-3H,3'H-[2,2']bithiazolyliden-5-yl]-ethanol
• CAS NO: 131352-74-4
• Molecular Weight: 466.668
• Mol File: 131352-74-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(Z)-3,3'-Dibenzyl-5'-(2-hydroxy-ethyl)-4,4'-dimethyl-3H,3'H-[2,2']bithiazolyliden-5-yl]-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(Z)-3,3'-Dibenzyl-5'-(2-hydroxy-ethyl)-4,4'-dimethyl-3H,3'H-[2,2']bithiazolyliden-5-yl]-ethanol(131352-74-4)
• EPA Substance Registry System: 2-[(Z)-3,3'-Dibenzyl-5'-(2-hydroxy-ethyl)-4,4'-dimethyl-3H,3'H-[2,2']bithiazolyliden-5-yl]-ethanol(131352-74-4)

Safety Data

• Hazardous Substances Data: 131352-74-4(Hazardous Substances Data)

Upstream product

• 4568-71-2 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride 

Relevant articles and documents

N-Heterocyclic Carbene Catalyzed Oxidative Coupling of Alkenes/ α-Bromoacetophenones with Aldehydes: A Facile Entry to α,β-Epoxy Ketones

A novel, N-heterocyclic carbene (NHC) catalyzed direct oxidative coupling of styrenes with aldehydes has been described for the synthesis of α,β-epoxy ketones in good yields. This unprecedented regioselective oxidative coupling employs NBS/DBU/DMSO (DBU=1,8-diazabicyclo [5.4. 0] undec-7-ene, DMSO=dimethylsulfoxide, NBS=N-bromosuccinimide) as an oxidative system at ambient conditions. Additionally, first NHC-catalyzed Darzens reaction of α-bromoketones and aldehydes under mild reaction conditions has also been described. Interestingly, mechanistic studies have revealed the preferred reactivity of NHC with alkene/α-bromoketone rather than aldehydes, thus proceeding via the ketodeoxy Breslow intermediate.