1313592-36-7Relevant academic research and scientific papers
Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4- dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways
Li, Qianbin,Wu, Jingde,Zheng, Hui,Liu, Kai,Guo, Tai L.,Liu, Yuying,Eblen, Scott T.,Grant, Steven,Zhang, Shijun
, p. 4526 - 4530 (2010)
A thiazolidine-2,4-dione derivative, 3-(2-aminoethyl)-5-(3-phenyl- propylidene)-thiazolidine-2,4-dione (2), was identified as a dual inhibitor of the Raf/MEK/ extracellular signal-regulated kinase (ERK) and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascades. The discovered compound inhibited cell proliferation, induced early apoptosis, and arrested cells in G0/G1 phase in human leukemia U937 cells. These results indicate its potential as a new lead compound to develop novel dual signaling pathway inhibitors and anticancer agents.
