1313611-67-4Relevant articles and documents
Synthesis and biological evaluation of 2′-oxo-2,3-dihydro-3′H- spiro[chromene-4,5′-[1,3]oxazolidin]-3′yl]acetic acid derivatives as aldose reductase inhibitors
Rapposelli, Simona,Da Settimo, Federico,Digiacomo, Maria,La Motta, Concettina,Lapucci, Annalina,Sartini, Stefania,Vanni, Michael
, p. 372 - 385 (2011)
Aldose reductase (ARL2) is the first enzyme in the polyol pathway which catalyzes the NADPH-dependent reduction of glucose to sorbitol. Its involvement on diabetic complications makes this enzyme a challenge therapeutic target widely investigated to limit