131364-46-0

Upstream product

• 131364-75-5 6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 131364-61-9 6-(4-Fluorophenyl)-3-methyl-4-oxo-2-(4-phenylpiperazino)pyrimidine-5-carbonitrile 
• 131364-60-8 2-(3-Chloroanilino)-6-(4-fluorophenyl)-3-methyl-4-oxopyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

Synthesis and characterization of derivatives of pyrimidine-5-carbonitrile and their biological screening

Some new 2-(substituted)-4-(4-fluorophenyl)-1,6-dihydro-1-methyl-6-oxopyrimidine-5-carbonitriles (2-9) have been prepared by condensation of 4-(4-fluorophenyl)-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile) with different pharmacologi

Chemotherapeutic agents, XVIII: Synthesis of pi-deficient pyrimidines and fused pyrimidines as leishmanicidal agents.

Synthesis of 6-aryl-5-cyano-2-thiouracils 1a-d from the condensation-cyclization of an aromatic aldehyde, thiourea and ethyl cyanoacetate has been described. Alkylation of 1a-d under different reaction conditions with mono- and dihalo-alkanes yielded 2, 3, and 6. Interaction of 1 with POCl3 provided halopyrimidines 8a,b. Nucleophilic substitution on 8 and 3 with aromatic amines gave 9a-d and 7a-d respectively. 6-Chloro-5-nitro-3-methyluracil (11) obtained by nitration of 10 underwent nucleophilic substitution with amines providing 12. Some of the compounds screened as leishmanicides did not exhibit any significant activity.