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Usage

Uses

Used in Pharmaceutical Industry:
(4R)-4-t-Butyl-1,2,3-oxathiazolidine-2,2-dioxide-3-carboxylic acid t-butyl ester, Min. 97% is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (4R)-4-t-Butyl-1,2,3-oxathiazolidine-2,2-dioxide-3-carboxylic acid t-butyl ester, Min. 97% may be utilized as a building block for the creation of novel agrochemicals, such as pesticides or herbicides. Its potential to be modified and combined with other compounds makes it a valuable asset in the development of new products for agricultural use.
Used in Organic Synthesis:
As a high-purity compound, (4R)-4-t-Butyl-1,2,3-oxathiazolidine-2,2-dioxide-3-carboxylic acid t-butyl ester, Min. 97% is used as a key intermediate in organic synthesis. Its specific properties and reactivity make it suitable for the development of various organic compounds, which can be applied in a wide range of industries beyond pharmaceuticals and agrochemicals.

Upstream product

• 26782-71-8 D-tert-leucine 
• 142618-92-6 (R)-2-N-<(1,1-dimethylethoxy)carbonyl>amino-3,3-dimethylbutanol 
• 3907-02-6 (2R)-2-amino-3,3-dimethylbutan-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

Synthesis method for tert-butyl 1,2,3-oxathiazolidine-3-carboxylic ester 2,2-dioxide compound

The invention relates to a synthesis method for a tert-butyl 1,2,3-oxathiazolidine-3-carboxylic ester 2,2-dioxide compound. The tert-butyl 1,2,3-oxathiazolidine-3-carboxylic ester 2,2-dioxide compoundhas a structural formula as shown in a formula I which is described in the specification. The synthesis method comprises the step of allowing a compound as shown in a formula II which is described inthe specification with sulfonyl chloride in the presence of an organic solvent to generate the compound as shown in the formula I. The structural formula of the compound as shown in the formula I andthe structural formula of the compound as shown in the formula II are described in the specification. The synthesis method disclosed by the invention is simple to operate; compared with a conventional published two-step method, the synthesis method provided by the invention only needs one step; and the synthesis method is more convenient, reduces byproducts, is high in yield, does not need to usea catalyst and a highly-toxic substance in the reaction, and is safe and low in cost.

The first synthesis of β-amino phosphonates using cyclic sulfamidates

Cyclic sulfamidates (prepared from α-amino acids and β-amino alcohols) have been used for the first time for the synthesis of novel β-amino phosphonates (chiral and achiral) by treatment with dialkyl phosphites using sodium hydride. 2-Substituted and 1,2-disubtituted β-amino phosphonates have efficiently been prepared following this method. The products are formed in high yield (79-84%) within 8-12 h.