1313712-87-6Relevant articles and documents
Glucose-responsive insulin multivesicular liposome as well as preparation method and application thereof
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Paragraph 0041-0044, (2021/07/21)
The invention discloses a glucose-responsive insulin multi-vesicular liposome as well as a preparation method and application thereof. The liposome is a glucose-responsive insulin multi-vesicular liposome loaded with a phenylboronic acid derivative, gluco
A synthetic approach toward a self-regulated insulin delivery system
Matsumoto, Akira,Ishii, Takehiko,Nishida, Junko,Matsumoto, Hiroko,Kataoka, Kazunori,Miyahara, Yuji
supporting information; experimental part, p. 2124 - 2128 (2012/04/18)
Protein-free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose-dependent changes in the state of hydration under physiological aqueous conditions. A localized dehydration of the gel surface to form a "skin layer" enabled control of the release of insulin from the gel. This dehydration is induced by fluctuations in the glucose concentration in the range between normo- and hyperglycemia. Copyright