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Relevant academic research and scientific papers

Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors

Methylation of histones by lysine methyltransferases (KMTases) plays important roles in regulating chromatin function. It is also now clear that improper KMTases activity is linked to human diseases, such as cancer. We report an approach that employs drug

LYSINE AND ARGININE METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER

Compounds having lysine or arginine methyltransferase inhibitory activity and their use in the treatment of diseases and conditions associated with inappropriate methyltransferase activity are disclosed. The compounds are of the general formula (I).