1313804-01-1Relevant academic research and scientific papers
Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement
Neitz, R. Jeffrey,Konradi, Andrei W.,Sham, Hing L.,Zmolek, Wes,Wong, Karina,Qin, Ann,Lorentzen, Colin,Nakamura, David,Quinn, Kevin P.,Sauer, John-Michael,Powell, Kyle,Ruslim, Lany,Chereau, David,Ren, Zhao,Anderson, John,Bard, Frederique,Yednock, Ted A.,Griswold-Prenner, Irene
, p. 3726 - 3729 (2011)
In this Letter, we describe the evolution of selective JNK3 inhibitors from 1, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs. Strong SAR was found for substitution of the naphthalene ring, as well as f
