1313813-69-2Relevant academic research and scientific papers
Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4- ones
Fenster, Erik,Long, Toby R.,Zang, Qin,Hill, David,Neuenswander, Benjamin,Lushington, Gerald H.,Zhou, Aihua,Santini, Conrad,Hanson, Paul R.
, p. 244 - 250 (2011/06/25)
The construction of a 225-member (3 × 5 × 15) library of thiadiazepan-1,1-dioxide-4-ones was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 184/225 sultams. Three sultam core scaffolds were prepared based upon the utilization of an aza-Michael reaction on a multifunctional vinyl sulfonamide linchpin. The library exploits peripheral diversity in the form of a sequential, two-step [3 + 2] Huisgen cycloaddition/Pd-catalyzed Suzuki-Miyaura coupling sequence.
