1313834-49-9

Upstream product

• 768-95-6 1-adamanthanol 
• 2237-36-7 4-methoxysalicylic acid 
• 7559-81-1 chlorokojic acid 
• 135078-29-4 C₁₈H₂₂O₄ 
• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 

Relevant academic research and scientific papers

NOVEL KOJIC ACID DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITIONS CONTAINING THE SAME FOR SKIN WHITENING

PURPOSE: A kojic acid derivative and a cosmetic composition containing the same for skin whitening are provided to suppress melanogenesis and pigmentation with skin safety and to be applied to an external use skin formulation. CONSTITUTION: A kojic acid d

Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities

We synthesized benzoate ester derivatives of kojic acid with and without adamantane moiety. Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities. However, depigmenting activity was not noted in a cell-based assay. Contrasting results were obtained for benzoate derivatives (3a-e) containing an adamantane moiety. Compounds 3a-e showed potent depigmenting activities without tyrosinase inhibitory activities. To the best of our knowledge, this is the first study showing the depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.