131385-39-2

Basic information

• Product Name: C₇₀H₁₂₉NO₁₄Si₃
• Synonyms: C₇₀H₁₂₉NO₁₄Si₃
• CAS NO: 131385-39-2
• Molecular Weight: 1293.05
• Mol File: 131385-39-2.mol

Chemical Properties

• CAS DataBase Reference: C₇₀H₁₂₉NO₁₄Si₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₇₀H₁₂₉NO₁₄Si₃(131385-39-2)
• EPA Substance Registry System: C₇₀H₁₂₉NO₁₄Si₃(131385-39-2)

Safety Data

• Hazardous Substances Data: 131385-39-2(Hazardous Substances Data)

Upstream product

• 123747-39-7 C₆₂H₁₀₉NO₁₂Si₂ 
• 104987-11-3 Tacrolimus 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 131385-38-1 C₆₄H₁₁₅NO₁₄Si₂ 

Downstream Products

• 131364-09-5 C₇₈H₁₆₂O₉Si₆ 
• 130612-71-4 C₇₂H₁₄₈O₉Si₅ 
• 130612-70-3 (10E,18E)-(2R,4S,5R,6S,8S,12R,15S,16S,17S)-12-Allyl-5-(tert-butyl-dimethyl-silanyloxy)-4,6-dimethoxy-19-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,8,10,16,18-pentamethyl-15-triisopropylsilanyloxy-nonadeca-10,18-diene-1,13,17-triol 

Relevant articles and documents

Efficient Degradation of FK-506 to a Versatile Synthetic Intermediate

An 11-step degradation of natural FK-506 (1) to selectively protected C10-C34 synthetic intermediate 2 has been accomplished in 14percent overall yield.The key steps include; (a) lead tetracetate mediated C9-C10 bond cleavage of 24,32-bis(triisopropylsilyl)-FK-506 (3), (b) simultaneous C10 ester, C22 ketone reduction/C26 oxygen deacylation, and (c) selective bis(triethylsilylation) of the resulting triols 7a,b.The degradate 2 is ready for reacylation at the C26 hydroxyl terminus; hydrolysis of the dimethyl acetal moiety then provides an aldehyde ready for homologation at the C10 terminus.