1313850-06-4Relevant academic research and scientific papers
Regioselective Synthesis of Trisubstituted Quinoxalines Mediated by Hypervalent Iodine Reagents
Ito, Ryota,Miura, Kasumi,Suzuki, Noriyuki,Suzuki, Yumiko,Takehara, Ren
, p. 16892 - 16900 (2021/12/06)
A facile and regioselective synthesis of quinoxalines, an important motif in medicinal chemistry and materials sciences, was developed. Despite their prospective utility, the regioselective preparation of trisubstituted quinoxalines has not been previously established. In the reported system, hypervalent iodine reagents catalyzed the annulation between α-iminoethanones ando-phenylenediamines in a chemo/regioselective manner to afford trisubstituted quinoxalines. Excellent regioselectivities (6:1 to 1:0) were achieved using [bis(trifluoroacetoxy)iodo]benzene and [bis(trifluoroacetoxy)iodo]pentafluorobenzene as annulation catalysts.
Synthesis of unsymmetrical benzils using N-heterocyclic carbene catalysis
Suzuki, Yumiko,Bakar, Abu,Tanoi, Takashi,Nomura, Naoko,Sato, Masayuki
experimental part, p. 4710 - 4715 (2011/06/27)
In this paper, we propose a novel and efficient method for the preparation of various unsymmetrical benzils. We first demonstrate the nucleophilic aroylation of N-phenylbenzimidoyl chlorides with aromatic aldehydes using N-heterocyclic carbene as the catalyst to afford 1-aryl-2-phenyl-2-(phenylimino) ethanones. These iminoethanones were then converted to 1,2-diaryl-1,2-diketones by acid-promoted hydrolysis.
