13140-70-0

Upstream product

• 504-24-5 4-aminopyridine 
• 103-72-0 phenyl isothiocyanate 
• 76105-84-5 pyridin-4-yl isothiocyanate 
• 62-53-3 aniline 

Downstream Products

• 1205532-86-0 CuCl(N-(4-pyridyl)-N'-phenylthiourea) 
• 1205532-88-2 CuI(N-(4-pyridyl)-N'-phenylthiourea) 

Relevant academic research and scientific papers

Ring opening polymerization of epoxides with urea-derivatives of 4-aminopyridine as thermally latent anionic initiator

In this study, a series of urea-derivatives of 4-aminopyridine (4AP) were evaluated as thermally latent initiators for the anionic ring-opening polymerization of diglycidyl ether of bisphenol A (DGEBA). The urea-derivatives were synthesized by the reactio

On the synthesis of pyridinylthiobarbituric acids

The reaction of N-(pyridin-3-yl) and -4-yl thiourea derivatives with malonyl dichloride in trifluoroacetic acid is shown to be an efficient synthesis of the corresponding thiobarbituric acids. The pyridin-2-yl analogue cleaved and produced, instead, 2-hyd

Synthesis and quantum calculations of 1,3-thiazoles and 1,3,4-thiadiazole derivatives via pyridinylthioureas

In this study, the reaction of 4- and 2-aminopyridines with phenyl isothiocyanate afforded the corresponding 1-phenyl-3-(pyridin-4-yl)thiourea 1 and its pyridin-2-yl analog 20. The reaction of 1 with ethyl chloroacetate gave 3-phenyl-2-(pyridin-4-ylimino)thiazolidin-4-one (3B), which upon a condensation reaction with aldehydes furnished 5-benzylidene derivatives 4a-c. Compounds 1 and 20 underwent heterocyclization upon their reaction with hydrazonoyl chloride 5 and gave the corresponding 1,3,4-thiadiazoles 8 and 22; however, the treatment of 1 and 20 with hydrazonoyl chloride 10 afforded the corresponding 1,3-thiazoles 14 and 25. The quantum calculations were studied using the density functional theory of the starting materials and some products.

Synthesis and in vitro urease inhibitory activity of N,N′- disubstituted thioureas

Thiourea derivatives (1-38) were synthesized and evaluated for their urease inhibition potential. The synthetic compounds showed a varying degree of in vitro urease inhibition with IC50 values 5.53 ± 0.02-91.50 ± 0.08 μM, most of which are superior to the standard thiourea (IC50 = 21.00 ± 0.11 μM). In order to ensure the mode of inhibition of these compounds, the kinetic study of the most active compounds has been carried out. Most of these inhibitors were found to be mixed-type of inhibitors, except compounds 13 and 30 which were competitive, while compound 19 was identified as non-competitive inhibitor with Ki values between 8.6 and 19.29 μM.

Hydrogen-bonding networks in heterocyclic thioureas

The synthesis of heterocyclic thioureas from heterocyclic amines with phenyl- or methylisothiocyanate or CS2 is described. Seven new X-ray crystal structures are reported: In N-(3-pyridyl)-N'-phenylthiourea (Pna2 1, a = 10.1453(3), b

High-pressure-promoted condensation of isothiocyanates with aminopyridines: Efficient synthesis of pyridine-thiourea conjugates as building blocks for hydrogen-bonding receptors

New N-pyridinothiourea derivatives have been prepared by the high-pressure-promoted condensation of isothiocyanates with aminopyridines under uncatalyzed conditions. Complexation of the prototype 3c with diphenyl hydrogen phosphate was investigated by 1H NMR, and the results suggest that it may be useful as a building block for hydrogen-bonding receptors.