13140-83-5

Basic information

• Product Name: N,N"-(methylenedi-4,1-phenylene)bis[N'-phenyl-Urea]
• Synonyms: N,N"-(methylenedi-4,1-phenylene)bis[N'-phenyl-Urea];N,N''-[methylenebis(4,1-phenylene)]bis(N'-phenylurea);1,1'-(methanediyldibenzene-4,1-diyl)bis(3-phenylurea)
• CAS NO: 13140-83-5
• Molecular Formula: C27H24 N4 O2
• Molecular Weight: 436.51
• Mol File: 13140-83-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N"-(methylenedi-4,1-phenylene)bis[N'-phenyl-Urea](CAS DataBase Reference)
• NIST Chemistry Reference: N,N"-(methylenedi-4,1-phenylene)bis[N'-phenyl-Urea](13140-83-5)
• EPA Substance Registry System: N,N"-(methylenedi-4,1-phenylene)bis[N'-phenyl-Urea](13140-83-5)

Safety Data

• Hazardous Substances Data: 13140-83-5(Hazardous Substances Data)

Upstream product

• 103-71-9 phenyl isocyanate 
• 101-77-9 4,4'-diamino diphenyl methane 

Relevant articles and documents

Design, in silico, one-pot synthesis, and biological evaluations of novel bis-urea analogs

Abstract: The structure of urea has received special attention due to its biological activity. A new and efficient one-pot three-component reaction for the synthesis of bis-urea compounds from a variety of substituted diamino derivatives and isocyanate derivatives at room temperature with suitable yield is reported. Seven novel bis-urea derivatives were designed, synthesized, isolated, purified, and characterized (3a–g) with a variety of aromatic and aliphatic linkers. All compounds were evaluated for their cytotoxic and antibacterial properties. Most of the synthesized compounds exhibited reasonable activity compared to the positive control group. Graphic abstract: Development of a novel one-pot three-component reaction (3-CR) for the preparation of bis-urea scaffolds based on in silico studies was done. Evaluations of cytotoxic and antibacterial activities of all compounds were done. Most of the compounds exhibited good activities.[Figure not available: see fulltext.].