13140-86-8

Basic information

• Product Name: 1-cyclopropyl-3-phenylurea
• Synonyms: urea, N-cyclopropyl-N'-phenyl-
• CAS NO: 13140-86-8
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.2151
• Mol File: 13140-86-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 280.9°C at 760 mmHg
• Flash Point: 118.2°C
• Density: 1.17g/cm³
• Vapor Pressure: 0.00369mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-cyclopropyl-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-3-phenylurea(13140-86-8)
• EPA Substance Registry System: 1-cyclopropyl-3-phenylurea(13140-86-8)

Safety Data

• Hazardous Substances Data: 13140-86-8(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 4747-72-2 isocyanatocyclopropane 
• 103-71-9 phenyl isocyanate 
• 765-30-0 Cyclopropylamine 

Relevant articles and documents

METHOD OF CONVERTING CARBON DIOXIDE INTO CARBONYL COMPOUNDS

The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by Figure 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from -40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from -40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

Synthesis of N-1′, N-3′-disubstituted spirohydantoins and their anticonvulsant activities in pilocarpine model of temporal lobe epilepsy

Herein we report the synthesis and anticonvulsant activity of a library of eighteen new compounds that are structural mimics of phenytoin. These class of compounds contain a N-1′, N-3′-disubstituted spirohydantoin scaffold, where the N-1′ and N-3′ positions are modified with an alkyl group or aryl group. Of the eighteen compounds synthesized and tested, compound 5c showed the best anticonvulsant activity. It completely prevented the precursor events of motor seizure in the pilocarpine model of temporal lobe epilepsy. Additionally, ten of the analogs were more effective than phenytoin when compared using the Racine's score in the pilocarpine model. Based on the structure activity relationship (SAR), we concluded that alkyl groups (ethyl, propyl or cyclopropyl) at N-3′ position and 4-nitro phenyl group at N-1′ position are desirable.