1314019-96-9Relevant academic research and scientific papers
BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
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Page/Page column 22, (2011/08/03)
A compound of the formula (1): wherein R1 represents C1-6 alkyl or H; Y represents -NR2R3 as depicted in formula (B), or a ring of formula (A) whereina represents the point of attachment to the pyrimidinyl ring; R2 represents C1-4halkyI substituted by C1-3 alkoxy; R3 represents C1-4 alkyl; W represents - (CH2)n-; W1 represents -(CH2)P-; n represents 1 or 2 or 3; p represents 1 or 2; R4 represents C1-4 alkoxy, C1-6 alkyl or halogen; and R5 represents halogen or H, provided that, when R4 represents halogen, R5 is not H, or a pharmaceutically acceptable salt thereof, is provided. The compounds of the invention have been found to modulate the histamine H3 receptor.
COMPOUNDS AND THEIR USE
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Page/Page column 8, (2011/08/02)
A compound of the formula: wherein: R1 represents C1-6 alkyl or H; Y represents —NR2R3 as depicted in formula (B), or a ring of formula (A) wherein a represents the point of attachment to the pyrimidinyl ring; R2 represents C1-4alkyl substituted by C1-3 alkoxy; R3 represents C1-4 alkyl; W represents —(CH2)n—; W1 represents —(CH2)p—; n represents 1 or 2 or 3; p represents 1 or 2; R4 represents C1-4 alkoxy, C1-6 alkyl or halogen; and R5 represents halogen or H, provided that, when R4 represents halogen, R5 is not H, or a pharmaceutically acceptable salt thereof. The compounds of the invention have been found to modulate the histamine H3 receptor.
