1314028-43-7

Basic information

• Product Name: 5'-O-(4,4')dimethoxytrityl-2'-O-⁽¹³⁾C-methyluridine
• Synonyms: 5'-O-(4,4')dimethoxytrityl-2'-O-⁽¹³⁾C-methyluridine
• CAS NO: 1314028-43-7
• Molecular Weight: 561.593
• Mol File: 1314028-43-7.mol

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4')dimethoxytrityl-2'-O-⁽¹³⁾C-methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4')dimethoxytrityl-2'-O-⁽¹³⁾C-methyluridine(1314028-43-7)
• EPA Substance Registry System: 5'-O-(4,4')dimethoxytrityl-2'-O-⁽¹³⁾C-methyluridine(1314028-43-7)

Safety Data

• Hazardous Substances Data: 1314028-43-7(Hazardous Substances Data)

Upstream product

• 173170-12-2 2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil 

Downstream Products

• 1314028-44-8 5'-O-(4,4')-dimethoxytrityl-2'-O-⁽¹³⁾C-methyluridine-3'-(2-cyanoethyl)-N,N'-diisopropylphoshoramidite 

Relevant articles and documents

Probing RNA dynamics via longitudinal exchange and CPMG relaxation dispersion NMR spectroscopy using a sensitive 13C-methyl label

The refolding kinetics of bistable RNA sequences were studied in unperturbed equilibrium via 13C exchange NMR spectroscopy. For this purpose a straightforward labeling technique was elaborated using a 2′-13C-methoxy uridine modification, which was prepared by a two-step synthesis and introduced into RNA using standard protocols. Using 13C longitudinal exchange NMR spectroscopy the refolding kinetics of a 20nt bistable RNA were characterized at temperatures between 298 and 310K, yielding the enthalpy and entropy differences between the conformers at equilibrium and the activation energy of the refolding process. The kinetics of a more stable 32nt bistable RNA could be analyzed by the same approach at elevated temperatures, i.e. at 314 and 316K. Finally, the dynamics of a multi-stable RNA able to fold into two hairpin-and a pseudo-knotted conformation was studied by 13C relaxation dispersion NMR spectroscopy.